TITLE PAGE: Role of P-glycoprotein in the Intestinal Absorption of Glabridin, An Active Flavonoid from the Root of Glycyrrhiza glabra
نویسندگان
چکیده
Department of General Surgery, the First Municipal Hospital of Guangzhou, Guangzhou, China (J Cao) Department of Pharmacy, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China (X Chen) Department of Pharmacology and Toxicology, Australian Institute of Chinese Medicine, Sydney, New South Wales 2118, Australia (J Liang & SF Zhou) Department of Nephrology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China (XQ Yu) Department of Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou, China (AL Xu) Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore (E Chan) School of Pharmacy, Faculty of Medical and Health Sciences, the University of Auckland, Auckland, New Zealand (JY Wen) DMD Fast Forward. Published on January 12, 2007 as doi:10.1124/dmd.106.010801
منابع مشابه
Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra.
Glabridin is a major constituent of the root of Glycyrrhiza glabra, which is commonly used in the treatment of cardiovascular and central nervous system diseases. This study aimed to investigate the role of P-glycoprotein (PgP/MDR1) in the intestinal absorption of glabridin. The systemic bioavailability of glabridin was approximately 7.5% in rats, but increased when combined with verapamil. In ...
متن کاملInvestigation of Phytochemical Variability, Antioxidant Activity and Ecological Conditions of Native Iranian Glycyrrhiza glabra L.
Licorice (Glycyrrhiza glabra L.) as a strategic and highly valuable medicinal plant in Iran with numerous beneficial pharmaceutical properties contributes substantially to Iranian herbs exports. In the present study, a variation on the phytochemical and antioxidant activity of 25 populations of valuable and profitable medicinal plant of G. glabra was investigated. The climate variables and soil...
متن کاملPotentiating effect of glabridin from Glycyrrhiza glabra on GABAA receptors
Extracts from Glycyrrhiza are traditionally used for the treatment of insomnia and anxiety. Glabridin is one of the main flavonoid compounds from Glycyrrhiza glabra and displays a broad range of biological properties. In the present work, we investigated the effect of glabridin on GABAA receptors. For this purpose, we employed the two-electrode voltage-clamp technique on Xenopus laevis oocytes ...
متن کاملGlabridin-induced vasorelaxation: Evidence for a role of BKCa channels and cyclic GMP
BACKGROUND AND PURPOSE Glabridin is a major flavonoid in Glycyrrhiza glabra (licorice) root, a traditional Asian medicine. Glabridin is reported to have anti-atherogenic, anti-inflammatory and anti-nephritic properties; however its effects on vascular tone remain unexplored. EXPERIMENTAL APPROACH We examined the effect of glabridin on rat main mesenteric artery using isometric myography and a...
متن کاملLeaves Antimicrobial Activity of Glycyrrhiza glabra L.
Licorice (Glycyrrhiza glabra L.) is an important medicinal plant. In this study, the antimicrobial activities of ethanolic and aqueous extracts from licorice leaves were studied compared to root extracts activities. Bacillus subtilis, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli, and Candida albicans were used as test organisms...
متن کامل